Rapid CD4+ T-cell turnover in HIV-1 infection:: a paradigm revisited

被引：59

作者：

Wolthers, KC

Schuitemaker, H

Miedema, F

机构：

[1] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Dept Clin Viroimmunol, NL-1066 CX Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Clin & Expt Immunol Lab, NL-1100 DD Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, NL-1100 DD Amsterdam, Netherlands

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 01期

关键词：

D O I：

10.1016/S0167-5699(97)01188-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although progression to AIDS has generally been believed to be related to exhaustion of the capacity for CD4(+) T-cell renewal due to persistently enhanced CD4(+) T-cell turnover, this view is now increasingly being challenged. Here, Katja Wolthers, Hanneke Schuitemaker and Frank Miedema discuss these new experimental findings and propose alternative explanations for CD4(+) T-cell depletion in human immunodeficiency virus 1 infection.

引用

页码：44 / 48

页数：5

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