Study of the required HLB for the solubilization of cholesterol in aqueous solution

被引：6

作者：

Schulz, PC ^{[1
]}

Moya, S ^{[1
]}

机构：

[1] Univ Nacl Sur, Dept Quim & Ing Qca, RA-8000 Bahia Blanca, Argentina

来源：

COLLOID AND POLYMER SCIENCE | 1998年 / 276卷 / 01期

关键词：

cholesterol; solubilization; HLB; mixed micelles; emulsions; critical micelle concentration;

D O I：

10.1007/s003960050213

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubilization of cholesterol by anionic surfactant mixtures was studied as a function of their HLB values. The relationship between the logarithm of the critical micelle concentration and the HLB value of the mixtures was not linear, which was attributed to a lack of strict additivity of the HLB values. The solubilized cholesterol/surfactant ratio was determined and it was found to be higher than that in bile salts in all the studied surfactant mixtures. Below HLB = 24, emulsions were obtained, and the remaining cholesterol was solid. Above that value, limpid solutions were obtained, giving a solubility maximum at HLB approximate to 35. The non-solubilized cholesterol was mainly in the form of lamellar mesophase.

引用

页码：87 / 91

页数：5

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