A nanocomposite material formed by benzofulvene polymer nanoparticles loaded with a potent 5-HT3 receptor antagonist (CR3124)

被引：8

作者：

Cappelli, Andrea ^{[1
,2
]}

Galeazzi, Simone ^{[1
,2
]}

Zanardi, Iacopo ^{[1
,2
]}

Travagli, Valter ^{[1
,2
]}

Anzini, Maurizio ^{[1
,2
]}

Mendichi, Raniero ^{[3
]}

Petralito, Stefania ^{[4
]}

Memoli, Adriana ^{[4
]}

Paccagnini, Eugenio ^{[5
]}

Peris, Walter ^{[6
]}

Giordani, Antonio ^{[6
]}

Makovec, Francesco ^{[6
]}

Fresta, Massimo ^{[7
]}

Vomero, Salvatore ^{[1
,2
]}

机构：

[1] Univ Siena, Dipartimento Farmaco Chim Tecnol, I-53100 Siena, Italy

[2] Univ Siena, European Res Ctr Drug Discovery & Dev, I-53100 Siena, Italy

[3] CNR, Ist Studio Macromol, I-20133 Milan, Italy

[4] Univ Roma La Sapienza, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy

[5] Univ Siena, Dipartimento Biol Evolut, I-53100 Siena, Italy

[6] Rottapharm SpA, I-20052 Monza, Italy

[7] Magna Graecia Univ Catanzaro, Dipartimento Sci Farmacobiol, I-88100 Catanzaro, Italy

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2010年 / 12卷 / 03期

关键词：

Nanoparticles; Polymer; Drug release; SEM; DSC; Nanomedicine; THERMOREVERSIBLE POLYMERIZATION; SYSTEM;

D O I：

10.1007/s11051-009-9638-6

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Poly-BF3a, a new hydrophobic polymer obtained by spontaneous polymerization of 1-methylene-3-phenyl-1H-indene, was found to give nanoparticles characterized by favorable shape and dimensions. Poly-BF3a nanoparticles were loaded with CR3124, a potent 5HT(3) antagonist, as a drug model by desolvation methods either in the absence or in the presence of polyethylene glycol (PEG1000) as a wetting agent. The SEM studies showed that the introduction of CR3124 into the preparation led to a variable degree of aggregation-cementation, which afforded a sort of nanocomposite material. In the absence of PEG1000, the drug molecule was found to stay in the amorphous state (DSC studies) when its percentage is not higher than 10% by weight. In vitro release experiments showed that the formation and stability of the dispersion as well as the drug release were remarkably affected by the presence of PEG1000, demonstrating its beneficial effect to the nanoparticle morphology and disaggregation.

引用

页码：895 / 903

页数：9

共 18 条

[1]

Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system [J].