Generation of effector CD8+T cells and their conversion to memory T cells

被引：218

作者：

Cui, Weiguo ^{[1
]}

Kaech, Susan M. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

来源：

IMMUNOLOGICAL REVIEWS | 2010年 / 236卷

关键词：

T cells; memory; cell differentiation; viral; transcription factors; vaccination; IL-7; RECEPTOR-ALPHA; TRANSCRIPTIONAL REPRESSOR BLIMP-1; IFN-GAMMA PRODUCTION; CUTTING EDGE; CLONAL EXPANSION; VIRAL-INFECTION; IN-VIVO; HOMEOSTATIC PROLIFERATION; SELECTIVE EXPRESSION; LINEAGE RELATIONSHIP;

D O I：

10.1111/j.1600-065X.2010.00926.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector-to-memory transition, and mature into multipotent, functional memory T cells that self-renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8+ T cells.

引用

页码：151 / 166

页数：16

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