Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei

被引：190

作者：

Hastings, MH

Herzog, ED

机构：

[1] MRC, Div Neurobiol, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Washington Univ, Dept Biol, St Louis, MO 63130 USA

来源：

JOURNAL OF BIOLOGICAL RHYTHMS | 2004年 / 19卷 / 05期

关键词：

entrainment; stability; Period gene; BMALl; vasopressin; vasoactive intestinal polypeptide; Cryptochrome; multielectrode; luciferase; fluorescent imaging;

D O I：

10.1177/0748730404268786

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The mammalian SCN contains a biological clock that drives remarkably precise circadian rhythms in vivo and in vitro. Recent advances have revealed molecular and cellular mechanisms required for the generation of these daily rhythms and their synchronization between SCN neurons and to the environmental light cycle. This review of the evidence for a cell-autonomous circadian pacemaker within specialized neurons of the SCN focuses on 6 genes implicated within the pacemaking mechanism, an additional 4 genes implicated in pathways from the pacemaker, and the intercellular and intracellular mechanisms that synchronize SCN neurons to each other and to solar time.

引用

收藏

页码：400 / 413

页数：14

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