Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins

被引：144

作者：

Seward, David J. ^{[1
]}

Cubberley, Gabrielle ^{[1
]}

Kim, Soojin ^{[1
]}

Schonewald, Matt ^{[1
]}

Zhang, Lian ^{[1
]}

Tripet, Brian ^{[1
]}

Bentley, David L. ^{[1
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Sch Med, Dept Biochem & Mol Genet, Aurora, CO 80045 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 03期

关键词：

D O I：

10.1038/nsmb1200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone H3 Lys4 trimethylation (H3-K4me3) is a conserved mark of actively transcribed chromatin. Using a conditional mutant of the yeast H3-K4 methyltransferase, Set1p, we demonstrate rapid turnover of H3-K4me3 and H3-K4me2 in vivo and show this process requires Yjr119Cp, of the JARID1 family of JmjC proteins. Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function as K4 demethylases in vivo.

引用

页码：240 / 242

页数：3

共 18 条

[1] Structural insights into histone demethylation by JMJD2 family members
Chen, Zhongzhou
Zang, Jianye
Whetstine, Johnathan
Hong, Xia
Davrazou, Foteini
Kutateladze, Tatiana G.
Simpson, Michael
Mao, Qilong
Pan, Cheol-Ho
Dai, Shaodong
Hagman, James
Hansen, Kirk
Shi, Yang
Zhang, Gongyi
[J]. CELL, 2006, 125 (04) : 691 - 702
[2] The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
Cloos, Paul A. C.
Christensen, Jesper
Agger, Karl
Maiolica, Alessio
Rappsilber, Juri
Antal, Torben
Hansen, Klaus H.
Helin, Kristian
[J]. NATURE, 2006, 442 (7100) : 307 - 311
[3] Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation
Jensen, LR
Amende, M
Gurok, U
Moser, B
Gimmel, V
Tzschach, A
Janecke, AR
Tariverdian, G
Chelly, J
Fryns, JP
Van Esch, H
Kleefstra, T
Hamel, B
Moraine, C
Gécz, J
Turner, G
Reinhardt, R
Kalscheuer, VM
Ropers, HH
Lenzner, S
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2005, 76 (02) : 227 - 236
[4] JmjC-domain-containing proteins and histone demethylation
Klose, Robert J.
Kallin, Eric M.
Zhang, Yi
[J]. NATURE REVIEWS GENETICS, 2006, 7 (09) : 715 - 727
[5] A novel gene (PLU-1) containing highly conserved putative DNA chromatin binding motifs is specifically up-regulated in breast cancer
Lu, PJ
Sundquist, K
Baeckstrom, D
Poulsom, R
Hanby, A
Meier-Ewert, S
Jones, T
Mitchell, M
Pitha-Rowe, P
Freemont, P
Taylor-Papadimitriou, J
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (22) : 15633 - 15645
[6] Targeted recruitment of set1 histone methylase by elongating pol II provides a localized mark and memory of recent transcriptional activity
Ng, HH
Robert, F
Young, RA
Struhl, K
[J]. MOLECULAR CELL, 2003, 11 (03) : 709 - 719
[7] A protein with similarity to the human retinoblastoma binding protein 2 acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis
Quadbeck-Seeger, C
Wanner, G
Huber, S
Kahmann, R
Kämper, J
[J]. MOLECULAR MICROBIOLOGY, 2000, 38 (01) : 154 - 166
[8] Histone H3 lysine 4 methylation patterns in higher eukaryotic genes
Schneider, R
Bannister, AJ
Myers, FA
Thorne, AW
Crane-Robinson, C
Kouzarides, T
[J]. NATURE CELL BIOLOGY, 2004, 6 (01) : 73 - 77
[9] Histone demethylation mediated by the nuclear arnine oxidase homolog LSD1
Shi, YJ
Lan, F
Matson, C
Mulligan, P
Whetstine, JR
Cole, PA
Casero, RA
Shi, Y
[J]. CELL, 2004, 119 (07) : 941 - 953
[10] Chromatin modifications by methylation and ubiquitination: Implications in the regulation of gene expression
Shilatifard, Ali
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 : 243 - 269

← 1 2 →