Gold catalysis in organic synthesis:: Efficient cycloisomerization of α-aminoallenes to 3-pyrrolines

被引：215

作者：

Morita, N ^{[1
]}

Krause, N ^{[1
]}

机构：

[1] Univ Dortmund, D-44221 Dortmund, Germany

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 22期

关键词：

D O I：

10.1021/ol0481838

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The gold(III) chloride-catalyzed cycloisomerization of various alpha-aminoallenes gave the corresponding 3-pyrrolines in good to high chemical yields. An interesting dependence of the chirality transfer and reactivity on the N-protecting group was observed. The 3-pyrrolines are highly useful intermediates for the synthesis of functionalized pyrrolines, pyrrolidines, and other natural products.

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页码：4121 / 4123

页数：3

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