Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R

被引:194
作者
Yukawa, Hideaki [1 ]
Omumasaba, Crispinus A.
Nonaka, Hiroshi
Kos, Peter
Okai, Naoko
Suzuki, Nobuaki
Suda, Masako
Tsuge, Yota
Watanabe, Junko
Ikeda, Yoko
Vertes, Alain A.
Inui, Masayuki
机构
[1] Res Inst Innovat Technol Earth, Microbiol Res Grp, Kyoto 6190292, Japan
[2] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300101, Japan
来源
MICROBIOLOGY-SGM | 2007年 / 153卷
关键词
2-COMPONENT SIGNAL-TRANSDUCTION; MICROBIAL GENE IDENTIFICATION; ESCHERICHIA-COLI K-12; MYCOBACTERIUM-TUBERCULOSIS; BACILLUS-SUBTILIS; CORYNEFORM BACTERIA; REGULATORY SYSTEM; AMINO-ACIDS; INSERTION-SEQUENCE; SIGMA FACTORS;
D O I
10.1099/mic.0.2006/003657-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The complete genome sequence of Corynebacterium glutamicum strain R was determined to allow its comparative analysis with other corynebacteria. The biology of corynebacteria was explored by refining the definition of the subset of genes that constitutes the corynebacterial core as well as those characteristic of saprophytic and pathogenic ecological niches. In addition, the relative scarcity of corynebacterial sigma factors and the plasticity of their two-component system machinery reflect their relatively exacting nutritional requirements and reduced membrane-associated and secreted proteins. The conservation of key genes and pathways between corynebacteria, mycobacteria and Nocardia validates the use of C. glutamicum to study fundamental processes that are conserved in slow-growing mycobacteria, including pathogenesis-associated mechanisms. The discovery of 39 novel genes in C. glutamicum R that have not been previously reported in other corynebacteria supports the rationale for sequencing additional corynebacterial genomes to better define the corynebacterial pan-genome and identify previously undetected metabolic pathways in these organisms.
引用
收藏
页码:1042 / 1058
页数:17
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