In human epidermis, β-defensin 2 is packaged in lamellar bodies

被引：115

作者：

Oren, A

Ganz, T

Liu, L

Meerloo, T

机构：

[1] Univ Calif Los Angeles, Geffen Sch Med, Dept Pathol & Med, Los Angeles, CA 90095 USA

[2] Vet Adm Med Ctr W Los Angeles, Dept Med, Los Angeles, CA 90073 USA

[3] Univ Calif San Diego, Sch Med, Dept Cellular & Mol Med, La Jolla, CA 92093 USA

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2003年 / 74卷 / 02期

关键词：

defensins; keratinocyte; lamellar bodies; electron microscopy; cryosection; immunogold;

D O I：

10.1016/S0014-4800(02)00023-0

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The skin presents a mechanical, as well as an immunological barrier to infection, and displays considerable innate immune capacity. Recently, cultured human keratinocytes were described to produce and export a microbicidal peptide human beta-defensin 2 (HBD-2). Immunogold was used to label ultrathin cryosections of stimulated, cultured human epidermis. HBD-2 was found to be stored in the lamellar bodies (LBs) of the stimulated keratinocytes of the spinous layer of the epidermis. HBD-2 was also found in the intercellular space. These findings suggest that HBD-2 is released with the contents of the LBs. Along with other investigations, our findings indicate that the lipid "permeability" barrier of the skin contains antimicrobial substances. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：180 / 182

页数：3