[1] Univ Durham, Sch Biol & Biomed Sci, Durham DH1 3LE, England
[2] Univ Newcastle, Int Ctr Life, Inst Human Genet, Newcastle Upon Tyne NE1 3BZ, Tyne & Wear, England
[3] Univ Newcastle, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England