Leptin

被引：483

作者：

Auwerx, J ^{[1
]}

Staels, B ^{[1
]}

机构：

[1] Inst Pasteur, INSERM, Dept Atherosclerose, Lab Biol Regulat Eucaryotes, F-59019 Lille, France

来源：

LANCET | 1998年 / 351卷 / 9104期

关键词：

D O I：

10.1016/S0140-6736(97)06348-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Leptin (from the Greek leptos=thin) was identified only 3 years ago. It has attracted huge attention both scentifically, with more than 600 publications, and in the media, where this protein has been portrayed as the way to a cure for obesity. Indeed, leptin was first described as an adipocyte-derived signalling factor, which, after interaction with its receptors, induced a complex response including control of bodyweight and energy expenditure. Leptin seems in addition to its role in metabolic control to have important roles In reproduction and neuroendocrine signalling. Human obesity is a complex disorder, with many factors playing a part; the pathophysiology of leptin is not as simple as it seems to be in rodent models of obesity.

引用

页码：737 / 742

页数：6

共 96 条

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