Distribution of olfactory receptor genes in the human genome

被引：172

作者：

Rouquier, S

Taviaux, S

Trask, BJ

Brand-Arpon, V

van den Engh, G

Demaille, J

Giorgi, D

机构：

[1] CNRS, CRBM, F-34293 Montpellier 5, France

[2] Univ Washington, Dept Mol Biotechnol, Seattle, WA 98195 USA

来源：

NATURE GENETICS | 1998年 / 18卷 / 03期

关键词：

D O I：

10.1038/ng0398-243

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We demonstrate that members of the olfactory receptor (OR) gene family are distributed on all but a few human chromosomes. Through FISH analysis, we show that OR sequences reside at move than 25 locations in the human genome. Their distribution is biased for terminal bands. Flow-sorted chromosomes were used to isolate 87 OR sequences derived from 16 chromosomes. Their sequence-relationships are indicative of the inter- and intrachromosomal duplications responsible for OR family expansion. The human genome has accumulated a striking number of dysfunctional copies: 72% of the sequences are pseudogenes. ORF-containing sequences predominate on chromosomes 7, 16 and 17.

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页码：243 / 250

页数：8

相关论文

共 35 条

[11] TOWARD A CDNA MAP OF THE HUMAN GENOME [J].

KORENBERG, JR ;

CHEN, XN ;

ADAMS, MD ;

VENTER, JC .

GENOMICS, 1995, 29 (02) :364-370

[12] OLFACTORY RECEPTORS [J].

LANCET, D ;

BENARIE, N .

CURRENT BIOLOGY, 1993, 3 (10) :668-674

[13] A SIMPLE METHOD FOR SIMULTANEOUS R-BANDING OR G-BANDING AND FLUORESCENCE INSITU HYBRIDIZATION OF SMALL SINGLE-COPY GENES [J].

LEMIEUX, N ;

DUTRILLAUX, B ;

VIEGASPEQUIGNOT, E .

CYTOGENETICS AND CELL GENETICS, 1992, 59 (04) :311-312

[14] EVOLUTION OF THE VERTEBRATE GENOME AS REFLECTED IN PARALOGOUS CHROMOSOMAL REGIONS IN MAN AND THE HOUSE MOUSE [J].

LUNDIN, LG .

GENOMICS, 1993, 16 (01) :1-19

[15] CLONING OF HUMAN GENES ENCODING NOVEL G-PROTEIN-COUPLED RECEPTORS [J].

MARCHESE, A ;

DOCHERTY, JM ;

NGUYEN, T ;

HEIBER, M ;

CHENG, R ;

HENG, HHQ ;

TSUI, LC ;

SHI, XM ;

GEORGE, SR ;

ODOWD, BF .

GENOMICS, 1994, 23 (03) :609-618

[16] Analysis of the variation in chromosome size among diverse human populations by bivariate flow karyotyping [J].

Mefford, H ;

vandenEngh, G ;

Friedman, C ;

Trask, BJ .

HUMAN GENETICS, 1997, 100 (01) :138-144

[17] CODING OF OLFACTORY INFORMATION - TOPOGRAPHY OF ODORANT RECEPTOR EXPRESSION IN THE CATFISH OLFACTORY EPITHELIUM [J].

NGAI, J ;

CHESS, A ;

DOWLING, MM ;

NECLES, N ;

MACAGNO, ER ;

AXEL, R .

CELL, 1993, 72 (05) :667-680

[18]

OHNO S, 1968, HEREDITAS-GENETISK A, V59, P169

[19] EXPRESSION OF MEMBERS OF THE PUTATIVE OLFACTORY RECEPTOR GENE FAMILY IN MAMMALIAN GERM-CELLS [J].

PARMENTIER, M ;

LIBERT, F ;

SCHURMANS, S ;

SCHIFFMANN, S ;

LEFORT, A ;

EGGERICKX, D ;

LEDENT, C ;

MOLLEREAU, C ;

GERARD, C ;

PERRET, J ;

GROOTEGOED, A ;

VASSART, G .

NATURE, 1992, 355 (6359) :453-455

[20] SEQUENCE ALIGNMENT OF THE G-PROTEIN COUPLED RECEPTOR SUPERFAMILY [J].

PROBST, WC ;

SNYDER, LA ;

SCHUSTER, DI ;

BROSIUS, J ;

SEALFON, SC .

DNA AND CELL BIOLOGY, 1992, 11 (01) :1-20

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