Elucidating a biological role for chromium at a molecular level

被引：249

作者：

Vincent, JB

机构：

[1] Univ Alabama, Dept Chem, Tuscaloosa, AL 35487 USA

[2] Univ Alabama, Coalit Biomol Prod, Tuscaloosa, AL 35487 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2000年 / 33卷 / 07期

关键词：

D O I：

10.1021/ar990073r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chromium is an essential trace element for mammals and is required for maintenance of proper carbohydrate and lipid metabolism. However, elucidating its function at a molecular level has proved to be problematic. Recent research has revealed that the chromium-binding oligopeptide chromodulin may play a unique role in the autoamplification of insulin signaling. Attempts to develop chromium-containing nutritional supplements and therapeutics are described.

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页码：503 / 510

页数：8

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