X inactivation and disease

被引：15

作者：

Agrelo, Ruben ^{[1
]}

Wutz, Anton ^{[1
]}

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 02期

关键词：

X inactivation; Xist RNA; Chromatin; Dosage compensation; Stem cells; Gene regulation; Epigenetics; XIST RNA; CHROMOSOME INACTIVATION; DNA METHYLATION; MOUSE; EXPRESSION; GENE; CHROMATIN; PROTEIN; LOCALIZATION; LYMPHOMA;

D O I：

10.1016/j.semcdb.2009.09.017

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

X inactivation is the mechanism by which mammals adjust the X-linked gene dosage between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in female cells. This dosage-compensation mechanism is based on the long functional Xist RNA. Here, we review our understanding of dosage compensation and Xist function in the context of disease. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：194 / 200

页数：7

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