Genetic models in pathogenesis

被引：49

作者：

Pradel, E ^{[1
]}

Ewbank, JJ ^{[1
]}

机构：

[1] Univ Mediterranee, Ctr Immunol Marseille Luminy, INSERM, CNRS, F-13288 Marseille 09, France

来源：

ANNUAL REVIEW OF GENETICS | 2004年 / 38卷

关键词：

infection; bacteria; host; virulence; immunity;

D O I：

10.1146/annurev.genet.38.072902.092528

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To decipher the complexity of host-pathogen interactions the widest possible range of model hosts and of analytical methods is required. As some virulence mechanisms and certain host responses have been conserved throughout evolution, even simple organisms can be used as model hosts to help our understanding of infectious diseases. The availability of molecular genetic tools and a cooperative community of researchers are pivotal to the emergence of model systems. In this review, we first summarize the genetic screens that can be used to identify pathogen virulence factors, then we present a comparative overview of existing or emerging genetically tractable host models.

引用

页码：347 / 363

页数：17

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