HGF/SF-Met signaling in tumor progression

被引：148

作者：

Gao, CF ^{[1
]}

Vande Woude, GF ^{[1
]}

机构：

[1] Van Andel Res Inst, Lab Mol Oncol, Grand Rapids, MI 49503 USA

来源：

CELL RESEARCH | 2005年 / 15卷 / 01期

关键词：

HGF/SF-Met; signaling; tumor progression;

D O I：

10.1038/sj.cr.7290264

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in primary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy.

引用

页码：49 / 51

页数：3

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