Correlations between genomic GC levels and optimal growth temperatures are not 'robust'

被引：28

作者：

Marashi, SA ^{[1
]}

Ghalanbor, Z ^{[1
]}

机构：

[1] Univ Tehran, Fac Sci, Dept Biotechnol, Tehran, Iran

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 325卷 / 02期

关键词：

GC content; DNA stability; prokaryotic genomes;

D O I：

10.1016/j.bbrc.2004.10.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Musto et al. [FEBS Lett. 573 (2004) 73] studied the correlations between GC levels and optimal growth temperatures in 20 prokaryotic families. They reported that positive correlations are generally observed, and many of these are significant. Here, we have shown that these correlations are not "robust," i.e., correlation coefficients and/or significance of correlations can be considerably influenced by exclusion of very few (even as small as one) species from each dataset. The sensitivity of correlations is assumed as a result of high levels of bias in the family datasets. We concluded that solely based on these data, one cannot establish that GC contents of prokaryotic genomes increase as a result of growth temperature increments. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：381 / 383

页数：3

共 5 条

[1] The universal ancestor was a thermophile or a hyperthermophile [J].