共 41 条
Lipid-protamine-DNA-mediated antigen delivery to antigen-presenting cells results in enhanced anti-tumor immune responses
被引:48
作者:

Dileo, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Pittsburgh, PA 15213 USA

Banerjee, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Pittsburgh, PA 15213 USA

Whitmore, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Pittsburgh, PA 15213 USA

Nayak, JV
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Pittsburgh, PA 15213 USA

Falo, LD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Pittsburgh, PA 15213 USA

Huang, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Pittsburgh, PA 15213 USA
机构:
[1] Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Dept Biochem & Mol Genet, Pittsburgh, PA 15213 USA
[3] Univ Pittsburgh, Dept Dermatol, Pittsburgh, PA 15213 USA
关键词:
liposome;
LPD;
peptide vaccine;
E7;
HPV;
cervical cancer;
D O I:
10.1016/S1525-0016(03)00064-9
中图分类号:
Q81 [生物工程学(生物技术)];
Q93 [微生物学];
学科分类号:
071005 ;
0836 ;
090102 ;
100705 ;
摘要:
Vaccination with antigenic peptides encoding tumor antigens has the potential to be an effective treatment for cancer. To induce tumor-specific cellular immune responses, a peptide antigen must be presented by antigen-presenting cells (APCs) to T-cells in the lymphatic tissues. Effective in vivo delivery of peptide antigens to APCs has been problematic. Here we use a model antigen from the HPV16 E7 protein to formulate LPD/E7 particles that upon iv administration are internalized by CD11c(+) and CD11b(+) cells in the marginal zone of the spleen. Either iv or sc vaccination with LPD/E7 particles induces E7-specific CTL responses stronger than those obtained using previously described liposome/peptide strategies and prevents the establishment of E7-expressing tumors. Furthermore, the administration of LPD/E7 particles to tumor-bearing mice caused complete tumor regression in 100% of the treated animals. Based on these studies, the entrapment of peptide antigens inside LPD particles may be an effective and generally applicable strategy for the enhancement of peptide vaccine potency.
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页码:640 / 648
页数:9
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