Free radical reactions for heterocycle synthesis. Part 6: 2-Bromobenzoic acids as building blocks in the construction of nitrogen heterocycles

被引：62

作者：

Zhang, W ^{[1
]}

Pugh, G ^{[1
]}

机构：

[1] DuPont Crop Protect, Lead Discovery, Stine Haskell Res Ctr, Newark, DE 19714 USA

来源：

TETRAHEDRON | 2003年 / 59卷 / 17期

关键词：

nitrogen heterocycles; pharmacophores; radical cyclization;

D O I：

10.1016/S0040-4020(03)00381-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general method to construct a variety of nitrogen heterocycles is introduced. 2-Bromobenzoic acids or acid chlorides are used as. the common building blocks to couple with appropriate nitrogen-containing compounds. Sequential aryl radical cyclizations including conjugate additions, spirocyclizations, homolytic and ipso aromatic substitutions, and 1,5-hydrogen atom transfers are employed to prepare tri- and tetracyclic isoindolinones, benzolactams, isoquinolinones, azabenzoisocoumarins, and bridged-azabicyclic compounds. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3009 / 3018

页数：10

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