A modular synthesis of the bis-tetrahydrofuran core of rolliniastatin from pyranoside precursors

被引：17

作者：

Ruan, ZM ^{[1
]}

Dabideen, D ^{[1
]}

Blumenstein, M ^{[1
]}

Mootoo, DR ^{[1
]}

机构：

[1] CUNY Hunter Coll, Dept Chem, New York, NY 10021 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 47期

基金：

美国国家卫生研究院;

关键词：

carbohydrates; iodoetherification; tetrahydrofuran; acetogenins;

D O I：

10.1016/S0040-4020(00)00878-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The iodoetherification of C6 allyllated 2,3-dideoxypyranosides has been shown to give cis-2,5-disubstituted tetrahydrofurans in high stereoselectivity. This result is applied to a modular synthesis of the bis-THF core of the acetogenin, rolliniastatin. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：9203 / 9211

页数：9

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