T cell aging: naive but not young

被引：85

作者：

Nikolich-Zugich, J ^{[1
]}

机构：

[1] Oregon Hlth Sci Univ, Beaverton, OR 97006 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 201卷 / 06期

关键词：

D O I：

10.1084/jem.20050341

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune system exhibits profound age-related changes, collectively termed immunosenescence. The most visible of these is the decline in protective immunity, which results from a complex interaction of primary immune defects and compensatory homeostatic mechanisms. The sum of these changes is a dysregulation of many processes that normally ensure optimal immune function. Recent advances suggest that old mice can produce fully functional new T cells, opening both intriguing inquiry avenues and raising critical questions to be pursued.

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页码：837 / 840

页数：4

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