Acyclic stereoselective boron alkylation reactions for the asymmetric synthesis of β-substituted α-amino acid derivatives

被引:42
作者
O'Donnell, MJ [1 ]
Cooper, JT
Mader, MM
机构
[1] Indiana Univ Purdue Univ, Dept Chem, Indianapolis, IN 46202 USA
[2] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
D O I
10.1021/ja0298794
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Optically active syn- or anti-β-substituted-α-amino acid derivatives are prepared in 94 to ≥99% ee and 66-98% ds by reaction of the Schiff base acetate of glycine tert-butyl ester with chiral, nonracemic B-alkyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine (CdOH) or cinchonine (CnOH), base, and lithium chloride. Copyright © 2003 American Chemical Society.
引用
收藏
页码:2370 / 2371
页数:2
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