Zyxin and paxillin proteins: focal adhesion plaque LIM domain proteins go nuclear

被引：125

作者：

Wang, Y ^{[1
]}

Gilmore, TD ^{[1
]}

机构：

[1] Boston Univ, Dept Biol, Boston, MA 02215 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2003年 / 1593卷 / 2-3期

关键词：

zyxin; paxillin; focal adhesion; LIM domain; nuclear-cytoplasmic shuttling; transcription;

D O I：

10.1016/S0167-4889(02)00349-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Zyxin and paxillin are the prototypes of two related subfamilies of LIM domain proteins that are localized primarily at focal adhesion plaques. However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. These proteins may enter the nucleus by association with other proteins, but are exported from the nucleus by means of intrinsic leucine-rich nuclear export sequences. Zyxin/paxillin proteins may regulate gene transcription by interaction with transcription factors. In some cases, misregulation of nuclear functions of zyxin/paxillin proteins appear to be associated with pathogenic effects. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：115 / 120

页数：6

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