Stimulation protocols for poor responders and aged women

被引：26

作者：

Barri, PN ^{[1
]}

Coroleu, B ^{[1
]}

Martinez, F ^{[1
]}

Veiga, A ^{[1
]}

机构：

[1] Univ Barcelona, Inst Dexeus, Dept Obstet & Gynecol, Serv Reprod Med, Barcelona 08017, Spain

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2000年 / 166卷 / 01期

关键词：

alternative protocols; natural cycle; oocyte donation; ovarian stimulation; poor-bad response;

D O I：

10.1016/S0303-7207(00)00292-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is a general consensus on the clinical fact that the more embryos replaced the higher pregnancy rates are achieved. For this reason those IVF cycles with a low response and a reduced number of oocytes and embryos will have very few chances of producing a pregnancy. It is very important to diagnose, by means of the anamnesis and hormonal tests which patients are most likely to present a poor response to conventional ovarian stimulation protocols. It is mandatory to know the patient's plasmatic levels of FSH and estradiol together with personal data such as the age and the previous history of the patient. Only young poor responders with a normal basal hormonal profile will have some chances that by applying new protocols and combining new drugs, improve their response and have higher pregnancy rates. For the old poor responders who have already failed to alternative protocols including natural cycles, oocyte donation is the last and best hope. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：15 / 20

页数：6

共 51 条

[11] Oocyte donation program: Pregnancy and implantation rates in women of different ages sharing oocytes from single donor [J].

Borini, A ;

Bianchi, L ;

Violini, F ;

Maccolini, A ;

Cattoli, M ;

Flamigni, C .

FERTILITY AND STERILITY, 1996, 65 (01) :94-97

[12]

BROWN JR, 1995, J REPROD MED, V40, P620

[13] The antral follicle count predicts the outcome of pregnancy in a controlled ovarian hyperstimulation intrauterine insemination program [J].

Chang, MY ;

Chiang, CH ;

Chiu, TH ;

Hsieh, TT ;

Soong, YK .

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1998, 15 (01) :12-17

[14]

ChristinMaitre S, 1996, CONTRACEPT FERTIL S, V24, P105

[15]

COROLEU B, 1999, REV IBEROAMERICANA F, V16, P259

[16] Inhibin-B as a test of ovarian reserve for infertile women [J].

Corson, SL ;

Gutmann, J ;

Batzer, FR ;

Wallace, H ;

Klein, N ;

Soules, MR .

HUMAN REPRODUCTION, 1999, 14 (11) :2818-2821

[17] Will GnRH antagonists provide new hope for patients considered 'difficult responders' to GnRH agonist protocols? [J].

Craft, I ;

Gorgy, A ;

Hill, J ;

Menon, D ;

Podsiadly, B .

HUMAN REPRODUCTION, 1999, 14 (12) :2959-2962

[18] Recombinant follicle stimulating hormone is effective in poor responders to highly purified follicle stimulating hormone [J].

De Placido, G ;

Alviggi, C ;

Mollo, A ;

Strina, I ;

Varricchio, MT ;

Molis, M .

HUMAN REPRODUCTION, 2000, 15 (01) :17-20

[19] Elevated levels of basal estradiol-17β predict poor response in patients with normal basal levels of follicle-stimulating hormone undergoing in vitro fertilization [J].

Evers, JLH ;

Slaats, P ;

Land, JA ;

Dumoulin, JCM ;

Dunselman, GAJ .

FERTILITY AND STERILITY, 1998, 69 (06) :1010-1014

[20] Cessation of gonadotropin-releasing hormone agonist therapy combined with high-dose gonadotropin stimulation yields favorable pregnancy results in low responders [J].

Faber, BM ;

Mayer, J ;

Cox, B ;

Jones, D ;

Toner, JP ;

Oehninger, S ;

Muasher, SJ .

FERTILITY AND STERILITY, 1998, 69 (05) :826-830

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