Antimycobacterial polyynes of Devil's Club (Oplopanax horridus), a North American native medicinal plant

被引：126

作者：

Kobaisy, M

Abramowski, Z

Lermer, L

Saxena, G

Hancock, REW

Towers, GHN

Doxsee, D

Stokes, RW

机构：

[1] UNIV BRITISH COLUMBIA,DEPT BOT,VANCOUVER,BC V6T 1Z3,CANADA

[2] UNIV BRITISH COLUMBIA,DEPT MICROBIOL,VANCOUVER,BC V6T 1Z3,CANADA

[3] UNIV BRITISH COLUMBIA,DEPT PAEDIAT,VANCOUVER,BC V5Z 4H4,CANADA

[4] BRITISH COLUMBIA CHILDRENS HOSP,BRITISH COLUMBIA RES INST CHILD & FAMILY HLTH,VANCOUVER,BC V5Z 4H4,CANADA

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 11期

关键词：

D O I：

10.1021/np970182j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new (3 and 5), as well as three known (1,2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae): a medicinal plant of North America. The structures were established by H-1 and C-13 NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 mu g/disk in a disk diffusion assay.

引用

页码：1210 / 1213

页数：4

共 25 条

[21] CORRELATION OF CONFIGURATION AND F-19 CHEMICAL-SHIFTS OF ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE DERIVATIVES [J].