Palladium-catalyzed borylation of phenyl bromides and application in one-pot Suzuki-Miyaura biphenyl synthesis

被引:109
作者
Broutin, PE [1 ]
Cerna, I [1 ]
Campaniello, M [1 ]
Leroux, F [1 ]
Colobert, F [1 ]
机构
[1] Univ Strasbourg 1, ECPM, CNRS, UMR 7008,Lab Stereochim, F-67087 Strasbourg 2, France
关键词
D O I
10.1021/ol048303b
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The coupling reaction of pinacolborane with various aryl bromides in the presence of a catalytic amount of Pd(OAc)(2) together with DPEphos as ligand and Et3N as base provided arylboronates. High yields were obtained in the case of electron-donor substituted aryl bromides. The direct preparation of arylboronates allowed the one-pot, two-step synthesis of unsymmetrical biaryls in high yields.
引用
收藏
页码:4419 / 4422
页数:4
相关论文
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