Gadolinium Chloride Augments Tumor-Specific Imaging of Targeted Quantum Dots In Vivo

被引：61

作者：

Diagaradjane, Parmeswaran ^{[1
]}

Deorukhkar, Amit ^{[1
]}

Gelovani, Juri G. ^{[2
]}

Maru, Dipen M. ^{[3
]}

Krishnan, Sunil ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA

来源：

ACS NANO | 2010年 / 4卷 / 07期

关键词：

gadolinium chloride; nanoparticle; imaging; Kupffer cell; quantum dots; KUPFFER CELL BLOCKADE; GROWTH-FACTOR RECEPTOR; RETICULOENDOTHELIAL BLOCKADE; CANCER; NANOPARTICLES; BIODISTRIBUTION; LIVER; MOUSE; LIPOSOMES; TOXICITY;

D O I：

10.1021/nn901919w

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Nonspecific sequestration of nanoparticles by the reticulo-endothelial system (RES) results in the degradation of image quality of nanoparticle-based imaging. We demonstrate that gadolinium chloride (GdCl3) pretreatment inactivates RES macrophages, thereby increasing circulatory time and amplifying the tumor-specific signal of conjugated nanoparticles in vivo. The experimental results were validated using compartmental modeling, and the rate parameters for the observed kinetics pattern were estimated. This pretreatment strategy could have broad applicability across biomedical applications utilizing theranostic nanoparticles that are sequestered by the RES.

引用

页码：4131 / 4141

页数：11

共 62 条

[1]

Kupffer cell blockade improves the endotoxin-induced microcirculatory inflammatory response in obstructive jaundice [J].

Abraham, Szabolcs ;

Szabo, Andrea ;

Kaszaki, Jozsef ;

Varga, Renata ;

Eder, Katalin ;

Duda, Erno ;

Lazar, Gyoergy ;

Tiszlavicz, Laszlo ;

Boros, Mihaly ;

Lazar, Gyoergy, Jr. .

SHOCK, 2008, 30 (01) :69-74

[2]

Nanocrystal targeting in vivo [J].

Åkerman, ME ;

Chan, WCW ;

Laakkonen, P ;

Bhatia, SN ;

Ruoslahti, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12617-12621

[3]

The use of nanocrystals in biological detection [J].

Alivisatos, P .

NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52

[4]

Quantum dots in biology and medicine [J].

Bailey, RE ;

Smith, AM ;

Nie, SM .

PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES, 2004, 25 (01) :1-12

[5]

Noninvasive imaging of quantum dots in mice [J].

Ballou, B ;

Lagerholm, BC ;

Ernst, LA ;

Bruchez, MP ;

Waggoner, AS .

BIOCONJUGATE CHEMISTRY, 2004, 15 (01) :79-86

[6]

Sentinel lymph node imaging using quantum dots in mouse tumor models [J].

Ballou, Byron ;

Ernst, Lauren A. ;

Andreko, Susan ;

Harper, Theresa ;

Fitzpatrick, James A. J. ;

Waggoner, Alan S. ;

Bruchez, Marcel P. .

BIOCONJUGATE CHEMISTRY, 2007, 18 (02) :389-396

[7]

Cys-diabody Quantum Dot Conjugates (ImmunoQdots) for Cancer Marker Detection [J].

Barat, Bhaswati ;

Sirk, Shannon J. ;

McCabe, Katelyn E. ;

Li, Jianqing ;

Lepin, Eric J. ;

Remenyi, Roland ;

Koh, Ai Leen ;

Olafsen, Tove ;

Gambhir, Sanjiv S. ;

Weiss, Shimon ;

Wu, Anna M. .

BIOCONJUGATE CHEMISTRY, 2009, 20 (08) :1474-1481

[8]

Nanoparticles in cancer therapy and diagnosis [J].

Brigger, I ;

Dubernet, C ;

Couvreur, P .

ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (05) :631-651

[9]

Semiconductor nanocrystals as fluorescent biological labels [J].

Bruchez, M ;

Moronne, M ;

Gin, P ;

Weiss, S ;

Alivisatos, AP .

SCIENCE, 1998, 281 (5385) :2013-2016

[10]

Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects [J].

Cai, WB ;

Shin, DW ;

Chen, K ;

Gheysens, O ;

Cao, QZ ;

Wang, SX ;

Gambhir, SS ;

Chen, XY .

NANO LETTERS, 2006, 6 (04) :669-676

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