Expression of FAP-1 (Fas-associated phosphatase) and resistance to Fas-mediated apoptosis in T cell lines derived from human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients

被引:42
作者
Arai, M
Kannagi, M
Matsuoka, M
Sato, T
Yamamoto, N
Fujii, M [1 ]
机构
[1] Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Bunkyo Ku, Tokyo 113, Japan
[2] Tokyo Med & Dent Univ, Div Med Res, Dept Microbiol, Tokyo 113, Japan
[3] Kumamoto Univ, Dept Internal Med 2, Kumamoto 860, Japan
[4] Columbia Univ, Dept Otolaryngol Pathol, New York, NY 10032 USA
关键词
D O I
10.1089/aid.1998.14.261
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human T cell leukemia virus type 1 (HTLV-I) is the etiologic agent of HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) with an autoimmune condition, We examined the sensitivity of HTLV-I-infected T cell lines to Fas-mediated apoptosis, which plays a critical role in the elimination of self-reactive T cells, Among 13 human T-cell lines, all 4 HAM-derived T cell lines and 4 of 6 non-HAM/HTLV-I T cell lines were resistant to apoptosis induced by anti-Fas antibody, whereas only 1 of 3 uninfected cell lines was resistant to apoptosis, The cell lines resistant to apoptosis expressed the viral tax gene and/or the cellular FAP-I (Fas-associated phosphatase) gene, both of which inhibit Fas-mediated apoptosis in T cell lines, Although Tax is a transcriptional activator of a number of cellular genes, the expression of Tax in a T cell line did not induce the expression of FAP-1, suggesting that these two antiapoptotic proteins independently function in HTLV-I-infected cells, Seven of 10 HTLV-I-infected cell lines, compared with only 1 of 3 virus-negative cell lines, expressed FAP-I, All four HAM cell lines expressed the FAP-I gene, and its level in these cells was higher than in other T cell lines, Our results suggest that virus-infected T cells escape Fas-mediated immune surveillance by the function of Tax and FAR-I, and this escape may be involved in the autoimmune condition observed in HAM/TSP patients.
引用
收藏
页码:261 / 267
页数:7
相关论文
共 40 条
  • [1] CHOMCZYNSKI P, 1993, BIOTECHNIQUES, V15, P532
  • [2] INHIBITION OF APOPTOSIS IN T-CELLS EXPRESSING HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I TAX
    COPELAND, KFT
    HAAKSMA, AGM
    GOUDSMIT, J
    KRAMMER, PH
    HEENEY, JL
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1994, 10 (10) : 1259 - 1268
  • [3] MONOCLONAL-ANTIBODY-MEDIATED APOPTOSIS IN ADULT T-CELL LEUKEMIA
    DEBATIN, KM
    GOLDMANN, CK
    BAMFORD, R
    WALDMANN, TA
    KRAMMER, PH
    [J]. LANCET, 1990, 335 (8688) : 497 - 500
  • [4] DOMINANT INTERFERING FAS GENE-MUTATIONS IMPAIR APOPTOSIS IN A HUMAN AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME
    FISHER, GH
    ROSENBERG, FJ
    STRAUS, SE
    DALE, JK
    MIDDELTON, LA
    LIN, AY
    STROBER, W
    LENARDO, MJ
    PUCK, JM
    [J]. CELL, 1995, 81 (06) : 935 - 946
  • [5] HUMAN T-CELL LEUKEMIA-VIRUS TYPE-1 (HTLV-1) TAX IS EXPRESSED AT THE SAME LEVEL IN INFECTED-CELLS OF HTLV-1-ASSOCIATED MYELOPATHY OR TROPICAL SPASTIC PARAPARESIS PATIENTS AS IN ASYMPTOMATIC CARRIERS BUT AT A LOWER LEVEL IN ADULT T-CELL LEUKEMIA-CELLS
    FURUKAWA, Y
    OSAME, M
    KUBOTA, R
    TARA, M
    YOSHIDA, M
    [J]. BLOOD, 1995, 85 (07) : 1865 - 1870
  • [6] GESSAIN A, 1985, LANCET, V2, P407
  • [7] EXOCRINOPATHY RESEMBLING SJOGRENS SYNDROME IN HTLV-1 TAX TRANSGENIC MICE
    GREEN, JE
    HINRICHS, SH
    VOGEL, J
    JAY, G
    [J]. NATURE, 1989, 341 (6237) : 72 - 74
  • [8] ADULT T-CELL LEUKEMIA - ANTIGEN IN AN ATL CELL-LINE AND DETECTION OF ANTIBODIES TO THE ANTIGEN IN HUMAN-SERA
    HINUMA, Y
    NAGATA, K
    HANAOKA, M
    NAKAI, M
    MATSUMOTO, T
    KINOSHITA, KI
    SHIRAKAWA, S
    MIYOSHI, I
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10): : 6476 - 6480
  • [9] HAM/TSP: Recent perspectives in Japan
    Ijichi, S
    Nakagawa, M
    Umehara, F
    Higuchi, I
    Arimura, K
    Izumo, S
    Osame, M
    [J]. JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1996, 13 : S26 - S32
  • [10] A RAT MODEL OF HUMAN LYMPHOCYTE-T VIRUS TYPE-I (HTLV-I) INFECTION .1. HUMORAL ANTIBODY-RESPONSE, PROVIRUS INTEGRATION, AND HTLV-I-ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS LIKE MYELOPATHY IN SERONEGATIVE HTLV-I CARRIER RATS
    ISHIGURO, N
    ABE, M
    SETO, K
    SAKURAI, H
    IKEDA, H
    WAKISAKA, A
    TOGASHI, T
    TATENO, M
    YOSHIKI, T
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) : 981 - 989