Ribozyme therapy for HIV infection

Within the past few years encouraging progress has been made in the treatment of HIV-I infection, largely due to the combined use of HIV-I protease inhibitors with nucleoside and non-nucleoside reverse transcriptase inhibitors. Despite this, HIV-I infection is still a major global problem and the emergence of a drug resistant virus is ever present. There is a continuing need to develop new therapeutic strategies as well as improve upon all forms of existing therapies for the treatment of this viral infection. It has now been almost a decade since the first demonstration that ribozymes can effectively inhibit HIV-I infectious spread in cell culture. Since then, ribozymes have progressed into human clinical trials primarily through gene therapy approaches. This progression brings ribozymes into the forefront as an important addition to the growing arsenal of anti-HIV-l weapons. The following review covers the developments in anti-HIV-l ribozyme usage over the past decade and summarizes the current state of ribozyme development for the purpose of inhibiting HIV-I infection. (C) 2000 Elsevier Science B.V. All rights reserved.