A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

被引:421
作者
Chen, Ruihuan [1 ]
Nishimura, Merry C. [1 ]
Bumbaca, Stephanie M. [1 ]
Kharbanda, Samir [1 ]
Forrest, William F. [2 ]
Kasman, Ian M. [1 ]
Greve, Joan M. [1 ]
Soriano, Robert H. [3 ]
Gilmour, Laurie L. [4 ]
Rivers, Celina Sanchez [3 ]
Modrusan, Zora [3 ]
Nacu, Serban [5 ]
Guerrero, Steve [5 ]
Edgar, Kyle A. [6 ]
Wallin, Jeffrey J. [6 ]
Lamszus, Katrin [7 ]
Westphal, Manfred [7 ]
Heim, Susanne [8 ]
James, C. David [9 ]
VandenBerg, Scott R. [9 ]
Costello, Joseph F. [9 ]
Moorefield, Scott [9 ]
Cowdrey, Cynthia J. [9 ]
Prados, Michael [9 ]
Phillips, Heidi S. [1 ,9 ]
机构
[1] Genentech Inc, Dept Tumor Biol & Angiogenesis, San Francisco, CA 94080 USA
[2] Genentech Inc, Dept Biostat, San Francisco, CA 94080 USA
[3] Genentech Inc, Dept Mol Biol, San Francisco, CA 94080 USA
[4] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
[5] Genentech Inc, Dept Bioinformat, San Francisco, CA 94080 USA
[6] Genentech Inc, Dept Canc Signaling, San Francisco, CA 94080 USA
[7] Univ Hamburg Eppendorf, D-20246 Hamburg, Germany
[8] Definiens AG, D-80339 Munich, Germany
[9] Univ Calif San Francisco, Brain Tumor Res Ctr, San Francisco, CA 94143 USA
基金
美国国家卫生研究院;
关键词
CANCER STEM-CELLS; NEURAL STEM/PROGENITOR CELLS; GLIOMA; IDENTIFICATION; PROGENITORS; ASTROCYTES; EXPRESSION; PROGNOSIS; FABP7; PROGRESSION;
D O I
10.1016/j.ccr.2009.12.049
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.
引用
收藏
页码:362 / 375
页数:14
相关论文
共 35 条
[11]   Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria [J].
Guenther, H. S. ;
Schmidt, N. O. ;
Phillips, H. S. ;
Kemming, D. ;
Kharbanda, S. ;
Soriano, R. ;
Modrusan, Z. ;
Meissner, H. ;
Westphal, M. ;
Lamszus, K. .
ONCOGENE, 2008, 27 (20) :2897-2909
[12]   Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis [J].
Iulianella, Angelo ;
Sharma, Madhulika ;
Durnin, Michael ;
Heuvel, Greg B. Vanden ;
Trainor, Paul A. .
DEVELOPMENT, 2008, 135 (04) :729-741
[13]   Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines [J].
Jaksch, Marie ;
Munera, Jorge ;
Bajpai, Ruchi ;
Terskikh, Alexey ;
Oshima, Robert G. .
CANCER RESEARCH, 2008, 68 (19) :7882-7886
[14]   Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas [J].
Joo, Kyeung Min ;
Kim, Shi Yean ;
Jin, Xun ;
Song, Sang Yong ;
Kong, Doo-Sik ;
Lee, Jung-Ii ;
Jeon, Ji Won ;
Kim, Mi Hyun ;
Kang, Bong Gu ;
Jung, Yong ;
Jin, Juyoun ;
Hong, Seung-Chyul ;
Park, Woong-Yang ;
Lee, Dong-Sup ;
Kim, Hyunggee ;
Nam, Do-Hyun .
LABORATORY INVESTIGATION, 2008, 88 (08) :808-815
[15]   FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status [J].
Kaloshi, Gentian ;
Mokhtari, Karima ;
Carpentier, Catherine ;
Taillibert, Sophie ;
Lejeune, Julie ;
Marie, Yannick ;
Delattre, Jean-Yves ;
Godbout, Roseline ;
Sanson, Marc .
JOURNAL OF NEURO-ONCOLOGY, 2007, 84 (03) :245-248
[16]   Selective targeting of cancer stem cells - A new concept in cancer therapeutics [J].
Korkaya, Hasan ;
Wicha, Max S. .
BIODRUGS, 2007, 21 (05) :299-310
[17]   Pten haploinsufficiency accelerates formation of high-grade astrocytomas [J].
Kwon, Chang-Hyuk ;
Zhao, Dawen ;
Chen, Jian ;
Alcantara, Sheila ;
Li, Yanjiao ;
Burns, Dennis K. ;
Mason, Ralph P. ;
Lee, Eva Y. -H. P. ;
Wu, Hong ;
Parada, Luis F. .
CANCER RESEARCH, 2008, 68 (09) :3286-3294
[18]   Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma [J].
Liang, Y ;
Bollen, AW ;
Aldape, KD ;
Gupta, N .
BMC CANCER, 2006, 6 (1)
[19]   Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Models [J].
Llaguno, Sheila Alcantara ;
Chen, Jian ;
Kwon, Chang-Hyuk ;
Jackson, Erica L. ;
Li, Yanjiao ;
Burns, Dennis K. ;
Alvarez-Buylla, Arturo ;
Parada, Luis F. .
CANCER CELL, 2009, 15 (01) :45-56
[20]   Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex [J].
Nieto, M ;
Monuki, ES ;
Tang, H ;
Imitola, J ;
Haubst, N ;
Khoury, SJ ;
Cunningham, J ;
Gotz, M ;
Walsh, CA .
JOURNAL OF COMPARATIVE NEUROLOGY, 2004, 479 (02) :168-180