Regioselectivity in a highly efficient, microwave-assisted epoxide aminolysis

被引：45

作者：

Desai, Hinal ^{[1
]}

D'Souza, Brendan R. ^{[1
]}

Foether, Devin ^{[1
]}

Johnson, Benjamin F. ^{[1
]}

Lindsay, Harriet A. ^{[1
]}

机构：

[1] Eastern Michigan Univ, Dept Chem, Ypsilanti, MI 48197 USA

来源：

SYNTHESIS-STUTTGART | 2007年 / 06期

关键词：

amino alcohols; amines; epoxides; regioselectivity; solvent effects;

D O I：

10.1055/s-2007-965927

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a microwave-assisted aminolysis of epoxides as an efficient method for synthesizing a number of 0-amino alcohols. In most cases, including in reactions of amines with a trisubstituted epoxide, only one equivalent of amine is required to obtain good yields. The reactions are consistently regioselective for amine nucleophiles of varying strengths and for both hindered and unhindered epoxides. In some cases, this regioselectivity could be enhanced by using a polar aprotic or a non-polar solvent.

引用

页码：902 / 910

页数：9

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