Acrylic polymeric nanospheres for the release and recognition of molecules of clinical interest

被引:51
作者
Ciardelli, G
Cioni, B
Cristallini, C
Barbani, N
Silvestri, D
Giusti, P
机构
[1] Dept Chem Engn, I-56126 Pisa, Italy
[2] CNR, Inst Composite & Biomed Mat, I-56100 Pisa, Italy
关键词
molecular imprinting; precipitation polymerisation; nanospheres; drug release; molecular recognition; theophylline;
D O I
10.1016/j.bios.2004.06.028
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Cross-linked poly(methylnlethacrylate-co-methacrylic acid) nanospheres were imprinted with theophylline through template radical polymerisation in diluted acetonitrile solution. This study will focus on the effect of functional monomer nature used (methylmethacrylate and/or methacrylic acid) in the recognition and in the release of template in order to develop a material with combined properties of drug delivery and rebinding, for clinical applications. After template extraction the nanospheres showed satisfactory recognition properties (up to 1 mg template/g of polymer). Moreover polymers prepared selectively removed theophylline with a theophylline rebinding of 5.1 times higher than that of caffeine. a compound of similar structure. Drug release properties were also satisfactory (up to 95% of loaded theophylline in 7 days). (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:1083 / 1090
页数:8
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