A simple and efficient FeCl3-catalyzed direct alkylation of active methylene compounds with benzylic and allylic alcohols under mild conditions

被引：144

作者：

Jana, Umasish ^{[1
]}

Biswas, Srijit ^{[1
]}

Maiti, Sukhendu ^{[1
]}

机构：

[1] Jadavpur Univ, Dept Chem, Kolkata 700032, W Bengal, India

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 23期

关键词：

ferric chloride; alkylation; active methylene compounds; alcohols; atom-economical;

D O I：

10.1016/j.tetlet.2007.04.017

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A highly efficient FeCl3-catalyzed alkylation of various active methylene compounds with various benzylic or allylic alcohols under mild conditions has been developed. The reaction was carried out in the presence of a catalytic amount of anhydrous FeCl3 (10 mol %) under reflux in methylene chloride. High to excellent yields were obtained. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4065 / 4069

页数：5

共 45 条

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Ir-catalysed allylic substitution: mechanistic aspects and asymmetric synthesis with phosphorus amidites as ligands [J].