POTENTIAL ROLE OF MICRO-RNAS IN HEAD AND NECK TUMORIGENESIS

被引：49

作者：

Tran, Nham ^{[1
,2
,3
]}

O'Brien, Christopher J. ^{[1
,2
]}

Clark, Jonathan ^{[1
,2
]}

Rose, Barbara ^{[1
,2
,4
]}

机构：

[1] Royal Prince Alfred Hosp, Sydney Head & Neck Canc Inst, Camperdown, NSW 2050, Australia

[2] Royal Prince Alfred Hosp, Sydney Canc Ctr, Camperdown, NSW 2050, Australia

[3] Royal Prince Alfred Hosp, Centenary Inst, Camperdown, NSW 2050, Australia

[4] Univ Sydney, Dept Infect Dis & Immunol, Sydney, NSW 2006, Australia

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2010年 / 32卷 / 08期

关键词：

head and neck; microRNAs; gene regulation; biomarkers; oncogenes; SQUAMOUS-CELL CARCINOMA; TUMOR-SUPPRESSIVE MICRORNAS; EXPRESSION PROFILES; LUNG-CANCER; GENE-EXPRESSION; POOR-PROGNOSIS; BREAST-CANCER; LET-7; MIR-21; OVEREXPRESSION;

D O I：

10.1002/hed.21356

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

A new class of regulatory molecules known as microRNAs (miRNAs) is redefining our understanding of the molecular pathways associated with tumorigenesis. These miRNAs are small noncoding RNA (ncRNA) sequences with potent regulatory potential. The aberrant expression of miRNAs has been associated with the development of various tumors. It has been suggested that miRNAs can both regulate and act as tumor-suppressor genes and oncogenes. Our understanding of the role of miRNAs in head and neck tumorigenesis is in its infancy. However, several recent studies have revealed extensive dysregulation of miRNA in head and neck tumors and have highlighted the potential of certain miRNAs to act as diagnostic and prognostic markers and targets for new therapeutic agents. The intent of this review is to discuss and summarize current findings that point to a significant role for miRNAs in head and neck tumorigenesis. (C) 2010 Wiley Periodicals, Inc. Head Neck 32: 1099-1111, 2010

引用

页码：1099 / 1111

页数：13

共 112 条

[1] let-7 microRNA functions as a potential growth suppressor in human colon cancer cells [J].