Genetic manipulation of schistosomes

被引：45

作者：

Brindley, Paul J. ^{[1
]}

Pearce, Edward J.

机构：

[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

[2] Tulane Univ, Hlth Sci Ctr, Dept Trop Med, New Orleans, LA 70112 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2007年 / 37卷 / 05期

关键词：

gene manipulation; schistosome; RNA interference; transgenesis; transfection; transformation; transduction; particle bombardment; biolistics; electroporation; reporter; promoter; parasitic helminth; functional genomics;

D O I：

10.1016/j.ijpara.2006.12.012

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In contrast to the situations with model organisms and parasitic protozoa, progress with gene manipulation with schistosomes has been delayed by impediments that include our inability to maintain the life cycle in vitro, absence of immortalized cell lines, large genome sizes, unavailability of drug resistance markers and other difficulties. However, in the past few years, tangible progress has been reported towards development of tools for gene manipulation and transgenesis of schistosomes, and there is reason to believe that the field is on the verge of transformation into an era where genetic manipulation is routine. Recent reports dealing with approaches and tools to manipulate the genome and gene expression in schistosomes are reviewed here. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：465 / 473

页数：9

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