A divergent protocol for solid-phase synthesis of highly substituted Bi-aryl furan derivatives

被引：15

作者：

Han, YX ^{[1
]}

Roy, A ^{[1
]}

Giroux, A ^{[1
]}

机构：

[1] Merck Frosst Canada & Co, Merck Frosst Ctr Therapeut Res, Dept Med Chem, Pointe Claire, PQ H9R 4P8, Canada

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 29期

关键词：

D O I：

10.1016/S0040-4039(00)00907-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile protocol for the solid-phase synthesis of highly substituted furan derivatives is discussed. This approach employs zincate 1 as the scaffold followed by sequential palladium-catalyzed cross-coupling reactions as the C-C bond-formation step. This methodology allows convenient modification of the furan core in three dimensions, giving rise to structurally diverse derivatives with overall good chemical purity and yield. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：5447 / 5451

页数：5

共 38 条

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