The error threshold

被引:143
作者
Biebricher, CK [1 ]
Eigen, M [1 ]
机构
[1] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany
关键词
quasispecies; replication; selection; mutation; sequence heterogeneity;
D O I
10.1016/j.virusres.2004.11.002
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Basic principles underlying the population dynamics of bacteria and viruses are presented, with emphasis on RNA viruses. Concepts reviewed here include fitness, mutant generation, competition, selection, sequence space and the theoretical origins of quasispecies. A "wild-type" virus is no longer viewed as the fittest type, but as the center of gravity of a population landscape. A consequence of quasispecies is the existence of an error threshold for selective competence. The error threshold has a justification in quasispecies theory and lends itself to exploration of strategies to drive viral populations over the error threshold, the central theme of this volume. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:117 / 127
页数:11
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