The error threshold

被引：143

作者：

Biebricher, CK ^{[1
]}

Eigen, M ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, D-37077 Gottingen, Germany

来源：

VIRUS RESEARCH | 2005年 / 107卷 / 02期

关键词：

quasispecies; replication; selection; mutation; sequence heterogeneity;

D O I：

10.1016/j.virusres.2004.11.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Basic principles underlying the population dynamics of bacteria and viruses are presented, with emphasis on RNA viruses. Concepts reviewed here include fitness, mutant generation, competition, selection, sequence space and the theoretical origins of quasispecies. A "wild-type" virus is no longer viewed as the fittest type, but as the center of gravity of a population landscape. A consequence of quasispecies is the existence of an error threshold for selective competence. The error threshold has a justification in quasispecies theory and lends itself to exploration of strategies to drive viral populations over the error threshold, the central theme of this volume. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：117 / 127

页数：11

共 59 条

[31] HAMMING RW, 1980, CODING INFORMATION T
[32] Nonquasispecies evidence for the evolution of RNA viruses
Jenkins, GM
Worobey, M
Woelk, CH
Holmes, EC
[J]. MOLECULAR BIOLOGY AND EVOLUTION, 2001, 18 (06) : 987 - 994
[33] JONES BL, 1976, B MATH BIOL, V38, P15
[34] HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE SUBSTITUTES FOR DNA-POLYMERASE-I IN ESCHERICHIA-COLI
KIM, B
LOEB, LA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (03) : 684 - 688
[35] Kimura Motoo., 1985, The Neutral Theory of Molecular Evolution
[36] Rapid evolution of translational control mechanisms in RNA genomes
Klovins, J
Tsareva, NA
deSmith, MH
Berzins, V
vanDuin, J
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1997, 265 (04) : 372 - 384
[37] LIEFER JR, 1998, NATURE, V391, P304
[38] Lethal mutagenesis of HIV with mutagenic nucleoside analogs
Loeb, LA
Essigmann, JM
Kazazi, F
Zhang, J
Rose, KD
Mullins, JI
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (04) : 1492 - 1497
[39] FIDELITY OF DNA-SYNTHESIS
LOEB, LA
KUNKEL, TA
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1982, 51 : 429 - 457
[40] FIDELITY OF DNA-REPLICATION
LOEB, LA
WEYMOUTH, LA
KUNKEL, TA
GOPINATHAN, KP
BECKMAN, RA
DUBE, DK
[J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1979, 43 : 921 - 927

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