Are large clinical trials in rapidly lethal diseases usually unethical?

被引：37

作者：

Horrobin, DF ^{[1
]}

机构：

[1] Laxdale Ltd, Stirling FK7 9JQ, Scotland

来源：

LANCET | 2003年 / 361卷 / 9358期

关键词：

D O I：

10.1016/S0140-6736(03)12571-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：695 / 697

页数：3

共 14 条

[1] Depletion of intracellular Ca2+ stores, phosphorylation of eIF2α, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole [J].

Aktas, H ;

Flückiger, R ;

Acosta, JA ;

Savage, JM ;

Palakurthi, SS ;

Halperin, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :8280-8285

[2] MEDICINE AND MATHEMATICS - STATISTICS AND ETHICS IN MEDICAL-RESEARCH .3. HOW LARGE A SAMPLE [J].

ALTMAN, DG .

BRITISH MEDICAL JOURNAL, 1980, 281 (6251) :1336-1338

[3]

Dreyling MH, 1997, CANCER RES, V57, P4608

[4] Why ''underpowered'' trials are not necessarily unethical [J].

Edwards, SJL ;

Lilford, RJ ;

Braunholtz, D ;

Jackson, J .

LANCET, 1997, 350 (9080) :804-807

[5] The continuing unethical conduct of underpowered clinical trials [J].

Halpern, SD ;

Karlawish, JHT ;

Berlin, JA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (03) :358-362

[6]

HORROBIN DF, 2002, BRIT MED J, V325, pA491

[7]

HORROBIN DF, IN PRESS MED HYPOTH

[8]

Hughes JR, 2002, JAMA-J AM MED ASSOC, V288, P2118

[9]

Janosky JE, 2002, JAMA-J AM MED ASSOC, V288, P2118, DOI 10.1001/jama.288.17.2118

[10]

Lilford RJ, 2002, JAMA-J AM MED ASSOC, V288, P2118

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