Ibuprofen, inflammation and Alzheimer disease

被引:53
作者
Wyss-Coray, T [1 ]
Mucke, L
机构
[1] Univ Calif San Francisco, Gladstone Inst Neurol Dis, San Francisco, CA 94141 USA
[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94141 USA
关键词
D O I
10.1038/79661
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mounting evidence suggests that non-steroidal anti-inflammatory drugs may be useful in reducing the risk of Alzheimer disease. After much study, the mechanism by which these drugs reduce the amyloid deposition associated with the disease is still open to speculation.
引用
收藏
页码:973 / 974
页数:2
相关论文
共 15 条
[1]   Inflammation and Alzheimer's disease [J].
Akiyama, H ;
Barger, S ;
Barnum, S ;
Bradt, B ;
Bauer, J ;
Cole, GM ;
Cooper, NR ;
Eikelenboom, P ;
Emmerling, M ;
Fiebich, BL ;
Finch, CE ;
Frautschy, S ;
Griffin, WST ;
Hampel, H ;
Hull, M ;
Landreth, G ;
Lue, LF ;
Mrak, R ;
Mackenzie, IR ;
McGeer, PL ;
O'Banion, MK ;
Pachter, J ;
Pasinetti, G ;
Plata-Salaman, C ;
Rogers, J ;
Rydel, R ;
Shen, Y ;
Streit, W ;
Strohmeyer, R ;
Tooyoma, I ;
Van Muiswinkel, FL ;
Veerhuis, R ;
Walker, D ;
Webster, S ;
Wegrzyniak, B ;
Wenk, G ;
Wyss-Coray, T .
NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421
[2]   Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [J].
Bales, KR ;
Verina, T ;
Dodel, RC ;
Du, YS ;
Altstiel, L ;
Bender, M ;
Hyslop, P ;
Johnstone, EM ;
Little, SP ;
Cummins, DJ ;
Piccardo, P ;
Ghetti, B ;
Paul, SM .
NATURE GENETICS, 1997, 17 (03) :263-264
[3]   CHARACTERIZATION OF MICROGLIA AND MACROPHAGES IN THE CENTRAL-NERVOUS-SYSTEM OF RATS - DEFINITION OF THE DIFFERENTIAL EXPRESSION OF MOLECULES USING STANDARD AND NOVEL MONOCLONAL-ANTIBODIES IN NORMAL CNS AND IN 4 MODELS OF PARENCHYMAL REACTION [J].
FLARIS, NA ;
DENSMORE, TL ;
MOLLESTON, MC ;
HICKEY, WF .
GLIA, 1993, 7 (01) :34-40
[4]   Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models [J].
Hsia, AY ;
Masliah, E ;
McConlogue, L ;
Yu, GQ ;
Tatsuno, G ;
Hu, K ;
Kholodenko, D ;
Malenka, RC ;
Nicoll, RA ;
Mucke, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :3228-3233
[5]   Cyclooxygenases and the central nervous system [J].
Kaufmann, WE ;
Andreasson, KL ;
Isakson, PC ;
Worley, PF .
PROSTAGLANDINS & OTHER LIPID MEDIATORS, 1997, 54 (03) :601-624
[6]   A beta amyloidogenesis: Unique, or variation on a systemic theme? [J].
Kisilevsky, R ;
Fraser, PE .
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1997, 32 (05) :361-404
[7]   Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs [J].
Lehmann, JM ;
Lenhard, JM ;
Oliver, BB ;
Ringold, GM ;
Kliewer, SA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (06) :3406-3410
[8]   Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease [J].
Lim, GP ;
Yang, F ;
Chu, T ;
Chen, P ;
Beech, W ;
Teter, B ;
Tran, T ;
Ubeda, O ;
Ashe, KH ;
Frautschy, SA ;
Cole, GM .
JOURNAL OF NEUROSCIENCE, 2000, 20 (15) :5709-5714
[9]   Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease [J].
Lue, LF ;
Kuo, YM ;
Roher, AE ;
Brachova, L ;
Shen, Y ;
Sue, L ;
Beach, T ;
Kurth, JH ;
Rydel, RE ;
Rogers, J .
AMERICAN JOURNAL OF PATHOLOGY, 1999, 155 (03) :853-862
[10]   High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice:: Synaptotoxicity without plaque formation [J].
Mucke, L ;
Masliah, E ;
Yu, GQ ;
Mallory, M ;
Rockenstein, EM ;
Tatsuno, G ;
Hu, K ;
Kholodenko, D ;
Johnson-Wood, K ;
McConlogue, L .
JOURNAL OF NEUROSCIENCE, 2000, 20 (11) :4050-4058