Odorant receptor heterodimerization in the olfactory system of Drosophila melanogaster

被引：242

作者：

Neuhaus, EM

Gisselmann, G

Zhang, WY

Dooley, R

Störtkuhl, K

Hatt, H

机构：

[1] Ruhr Univ Bochum, Lehrstuhl Zellphysiol, D-44780 Bochum, Germany

[2] Ruhr Univ Bochum, AG Sinnesphysiol, D-44780 Bochum, Germany

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 01期

关键词：

D O I：

10.1038/nn1371

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Despite increasing knowledge about dimerization of G-protein-coupled receptors, nothing is known about dimerization in the largest subfamily, odorant receptors. Using a combination of biochemical and electrophysiological approaches, we demonstrate here that odorant receptors can dimerize. DOR83b, an odorant receptor that is ubiquitously expressed in olfactory neurons from Drosophila melanogaster and highly conserved among insect species, forms heterodimeric complexes with other odorant-receptor proteins, which strongly increases their functionality.

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页码：15 / 17

页数：3

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