Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo

被引：279

作者：

Sun, YX

Schneider, A

Jung, Y

Wang, J

Dai, JL

Wang, JC

Cook, K

Osman, NI

Koh-Paige, AJ

Shim, H

Pienta, KJ

Keller, ET

McCauley, LK

Taichman, RS

机构：

[1] Univ Michigan, Sch Dent, Dept Periodont Prevent Geriatr, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Urol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Undergrad Res Opportun Program, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA

[5] Emory Univ, Winship Canc Inst, Dept Hematol Oncol, Atlanta, GA 30322 USA

[6] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA

[7] Emory Univ, Sch Med, Div Internal Med & Urol, Atlanta, GA 30322 USA

[8] Emory Univ, Sch Med, Dept Pathol, Atlanta, GA 30322 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期

关键词：

metastasis; chemokine; marrow; prostate cancer; bone;

D O I：

10.1359/JBMR.041109

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To delineate the role of SDF-1 and CXCR4 in metastatic prostate cancer (CaP), positive correlations were established between SDF-1 levels and tumor metastasis. Neutralization of CXCR4 limited the number and the growth of intraosseous metastasis in vivo. Together, these in vivo metastasis data provide critical support that SDF-1/CXCR4 plays a role in skeletal metastasis.

引用

页码：318 / 329

页数：12

共 49 条

[1] The CXC chemokine, monokine induced by interferon-γ, inhibits non-small cell lung carcinoma tumor growth and metastasis [J].