Functions of α3β1 integrin

被引:162
作者
Kreidberg, JA
机构
[1] Childrens Hosp, Dept Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA
关键词
D O I
10.1016/S0955-0674(00)00130-7
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
alpha 3 beta 1 integrin is a laminin receptor with apparently diverse functions. In epithelial cells it acts as a receptor for the basement membrane, whereas in neuronal and possibly tumor cells it mediates migration. Interactions of alpha 3 beta 1 integrin with tetraspanin proteins may provide clues to how it transduces signals that affect cell behavior.
引用
收藏
页码:548 / 553
页数:6
相关论文
共 62 条
[21]   Integrin alpha 6A beta 1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate [J].
Domanico, SZ ;
Pelletier, AJ ;
Havran, WL ;
Quaranta, V .
MOLECULAR BIOLOGY OF THE CELL, 1997, 8 (11) :2253-2265
[22]   beta 4 integrin is required for hemidesmosome formation, cell adhesion and cell survival [J].
Dowling, J ;
Yu, QC ;
Fuchs, E .
JOURNAL OF CELL BIOLOGY, 1996, 134 (02) :559-572
[23]  
DULABON L, 2000, IN PRESS NEURON
[24]   RECEPTOR FUNCTIONS FOR THE INTEGRIN VLA-3 - FIBRONECTIN, COLLAGEN, AND LAMININ BINDING ARE DIFFERENTIALLY INFLUENCED BY ARG-GLY-ASP PEPTIDE AND BY DIVALENT-CATIONS [J].
ELICES, MJ ;
URRY, LA ;
HEMLER, ME .
JOURNAL OF CELL BIOLOGY, 1991, 112 (01) :169-181
[25]  
Goldfinger LE, 1999, J CELL SCI, V112, P2615
[26]   A cell signal pathway involving laminin-5, α3β1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation [J].
Gonzales, M ;
Haan, K ;
Baker, SE ;
Fitchmun, M ;
Todorov, I ;
Weitzman, S ;
Jones, JCR .
MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (02) :259-270
[27]  
Guo NH, 2000, CANCER RES, V60, P457
[28]  
Hadjiargyrou M, 1996, J NEUROCHEM, V67, P2505
[29]  
HERTLE MD, 1991, DEVELOPMENT, V112, P193
[30]   Novel roles for α3 β1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes [J].
Hodivala-Dilke, KM ;
DiPersio, CM ;
Kreidberg, JA ;
Hynes, RO .
JOURNAL OF CELL BIOLOGY, 1998, 142 (05) :1357-1369