The effects of intestinal infusion of long-chain fatty acids on food intake in humans

被引:83
作者
French, SJ
Conlon, CA
Mutuma, ST
Arnold, M
Read, NW
Meijer, G
Francis, J
机构
[1] Univ Sheffield, No Gen Hosp, Ctr Human Nutr, Sheffield S5 7AU, S Yorkshire, England
[2] Inst Anim Sci Physiol & Anim Husb, Zurich, Switzerland
[3] Lipton, Englewood Cliffs, NJ USA
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1053/gast.2000.18139
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background & Aims: Dietary fat intake is related to the degree of obesity, but the specific mechanisms by which fats regulate food intake in humans ave unclear. We compared food intake suppression, plasma triglyceride appearance, and cholecystokinin (CCK) response after intestinal infusion of oils enriched with C18 fatty acids of increasing unsaturation, Methods: Food intake and appetite changes after upper intestinal infusion of 0.9% saline, 20% Intralipid,and 20% emulsions of oils enriched with stearic, oleic, and linoleic acids were tested in 10 healthy male volunteers. Plasma triglyceride appearance and CCK, release were tested separately in 7 additional volunteers. Results: Intralipid and linoleic acid infusions significantly reduced food intake compared with saline infusion (P < 0.05), No changes were observed in appetite ratings. There were no differences in plasma triglyceride response over the initial 75 minutes of intestinal infusion. Plasma CCK concentration increased after all lipid infusions (P < 0.001), Intralipid infusion produced the highest increase in plasma CCK (P < 0.05), and CCK response was similar between the 3 enriched oil emulsions. Conclusions: These results indicate marked differences in the ability of C18 fatty acids to reduce food intake that appear not to be related to rate of absorption but may partially be explained by CCK release.
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页码:943 / 948
页数:6
相关论文
共 36 条
[1]   CHOLECYSTOKININ IS A SATIETY HORMONE IN HUMANS AT PHYSIOLOGICAL POSTPRANDIAL PLASMA-CONCENTRATIONS [J].
BALLINGER, A ;
MCLOUGHLIN, L ;
MEDBAK, S ;
CLARK, M .
CLINICAL SCIENCE, 1995, 89 (04) :375-381
[2]  
BEARDSHALL K, 1989, LANCET, V2, P1008
[3]   DIFFERENTIAL INTESTINAL-ABSORPTION OF 2 FATTY-ACID ISOMERS - ELAIDIC AND OLEIC ACIDS [J].
BERNARD, A ;
ECHINARD, B ;
CARLIER, H .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (06) :G751-G759
[4]   Fat as a risk factor for overconsumption: Satiation, satiety, and patterns of eating [J].
Blundell, JE ;
Macdiarmid, JI .
JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 1997, 97 (07) :S63-S69
[5]   EFFECT OF TRIGLYCERIDE STRUCTURE ON FAT-ABSORPTION [J].
BRACCO, U .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1994, 60 (06) :1002S-1009S
[6]   Dietary fat intake does affect obesity! [J].
Bray, GA ;
Popkin, BM .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 68 (06) :1157-1173
[7]  
BRENER W, 1983, GASTROENTEROLOGY, V85, P76
[8]   Food intake responses to upper gastrointestinal lipid infusions in humans [J].
Castiglione, KE ;
Read, NW ;
French, SJ .
PHYSIOLOGY & BEHAVIOR, 1998, 64 (02) :141-145
[9]  
COHN JS, 1988, J LIPID RES, V29, P469
[10]   SUR LINCORPORATION DES CHAINES STEARIQUES DANS LES CHYLOMICRONS LYMPHATIQUES DU RAT [J].
CONSTANTIN, MJ ;
SAVARY, P .
BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 106 (02) :248-+