DNA polymerase proofreading: Multiple roles maintain genome stability

被引：121

作者：

Reha-Krantz, Linda J. ^{[1
]}

机构：

[1] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS | 2010年 / 1804卷 / 05期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

DNA polymerase proofreading; DNA replication fidelity; Mutator and antimutator DNA polymerases; Proofreading pathway; Active site switching; Okazaki fragment maturation; DEOXYRIBONUCLEIC-ACID POLYMERASE; 5 EXONUCLEASE ACTIVITY; OKAZAKI FRAGMENT MATURATION; ESCHERICHIA-COLI; SACCHAROMYCES-CEREVISIAE; AMINO-ACID; CRYSTAL-STRUCTURE; 2-AMINOPURINE FLUORESCENCE; MISMATCH REPAIR; ENZYMATIC-SYNTHESIS;

D O I：

10.1016/j.bbapap.2009.06.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA polymerase proofreading is a spell-checking activity that enables DNA polymerases to remove newly made nucleotide incorporation errors from the primer terminus before further primer extension and also prevents translesion synthesis. DNA polymerase proofreading improves replication fidelity similar to 100-fold, which is required by many organisms to prevent unacceptably high, life threatening mutation loads. DNA polymerase proofreading has been studied by geneticists and biochemists for >35 years. A historical perspective and the basic features of DNA polymerase proofreading are described here, but the goal of this review is to present recent advances in the elucidation of the proofreading pathway and to describe roles of DNA polymerase proofreading beyond mismatch correction that are also important for maintaining genome stability. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1049 / 1063

页数：15

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