Joining and scission in the self-assembly of nanotubes from DNA tiles

被引：56

作者：

Ekani-Nkodo, A ^{[1
]}

Kumar, A

Fygenson, DK

机构：

[1] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA

[2] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA

[3] Univ Calif Santa Barbara, Biomol Sci & Engn Program, Santa Barbara, CA 93106 USA

来源：

PHYSICAL REVIEW LETTERS | 2004年 / 93卷 / 26期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevLett.93.268301

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We present the first direct observations of tile-based DNA self-assembly in solution using fluorescent nanotubes composed of a single tile. The nanotubes reach tens of microns in length by end-to-end joining rather than by sequential addition of single tiles. Their exponential length distributions withstand dilution but decay via scission upon heating, with an energy barrier E(sc)similar to180k(B)T. DNA nanotubes are thus uniquely accessible equilibrium polymers that enable new approaches to optimizing DNA-based programming and understanding the biologically programmed self-assembly of protein polymers.

引用

页数：4

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