Low day 3 luteinizing hormone values are predictive of reduced response to ovarian stimulation

被引:34
作者
Noci, I
Biagiotti, R
Maggi, M
Ricci, F
Cinotti, A
Scarselli, G
机构
[1] Univ Florence, Dept Obstet & Gynaecol, Florence, Italy
[2] Univ Florence, Dept Clin Physiopathol, Androl Unit, Florence, Italy
关键词
luteinizing hormone; ovarian reserve; ovarian stimulation;
D O I
10.1093/humrep/13.3.531
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The aim of the present work was to evaluate whether low day 3 luteinizing hormone (LH) values in the presence of normal follicle stimulating hormone (FSH) are predictive of poor response to ovarian stimulation. Two groups of women undergoing ovarian stimulation and differing only in the day 3 LH concentration (<3 mIU/ml, study group, n = 30; >3 mIU/ml, control group, n = 45) were retrospectively analysed. Study group patients developed a lower oestradiol peak (703 +/- 388 versus 955 +/- 400 ng/ml; P = 0.005) and a lower number of follicles >15 mm diameter at the time of human chorionic gonadotrophin (HCG) administration (2.6 +/- 1.3 versus 3.6 +/- 1.8; P = 0.004) than the control group. Conversely, a similar ratio of oestradiol: follicles >15 mm diameter was observed (256 +/- 118 versus 269 +/- 93; P = 0.563), The number of follicles >10 mm at the time of HCG administration appeared to be lower in the study group, but this difference was not statistically significant (6 +/- 3.9 versus 7.8 +/- 4.3). Our data indicate that day 3 LH values <3 mIU/ml are predictive of poor response to ovarian stimulation.
引用
收藏
页码:531 / 534
页数:4
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