INSULIN-LIKE GROWTH-FACTORS - THE OVARIAN CONNECTION

被引：100

作者：

ADASHI, EY

RESNICK, CE

HURWITZ, A

RICCIARELLI, E

HERNANDEZ, ER

ROBERTS, CT

LEROITH, D

ROSENFELD, R

机构：

[1] Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore

[2] NIH, NIDDK, Bethesda

[3] Pediatric Endocrinology, Stanford University Medical Center, Stanford

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 09期

关键词：

INSULIN-LIKE GROWTH FACTOR (IGF); IGFBP; RECEPTOR; CAMP; SYNERGISM;

D O I：

10.1093/oxfordjournals.humrep.a137514

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A large body of information now supports the existence of a complete intraovarian insulin-like growth factor (IGF) system replete with ligands, receptors, and binding proteins. Although much remains to be learned, the emerging consensus would suggest that the intraovarian IGF system is concerned largely with the amplification of gonadotrophin hormonal action for the facilitation of follicular growth and development. Future studies are likely to address the central issue of indispensability and the documentation of a meaningful in vivo role for this and related putative intraovarian regulators.

引用

页码：1213 / 1219

页数：7

共 73 条

[1] Adashi E.Y., Resnick C.E., Brodie A.M.H., Svoboda M.E., Van Wyk J.J., Somatomedin-C-mediated potentiation of follicle-stimulating hormone-induced aromatase activity of cultured rat granulosa cells, Endocrinology, 11, pp. 2313-2320, (1985)
[2] Adashi E.Y., Resnick C.E., Brodie A.M.H., Svoboda M.E., Van Wyk J.J., Somatomedin-C enhances induction of luteinizing hormone receptors by follicle-stimulating hormone in cultured rat granulosa cells, Endocrinology, 11, pp. 2369-2375, (1985)
[3] Adashi E.Y., Resnick C.E., D'Ercole J., Svoboda M.E., Van Wyk J.J., Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function, Endocrinol. Rev, 6, pp. 400-420, (1985)
[4] Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J., Somatomedin-C synergizes with follicle stimulating hormone in the acquisition of progesterone biosynthetic capacity by cultured rat granulosa cells, Endocrinology, 11, pp. 2135-2142, (1985)
[5] Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J., Follicle-stimulating hormone enhances somatomedin-C binding to cultured rat granulosa cells: Evidence for cAMP-dependence, J. Biol. Chem, 26, (1986)
[6] Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J., Hascall V.C., Yanagishita M., Independent and synergistic actions of somatomedin-C in the stimulation of proteoglycan biosynthesis by cultured rat granulosa cells, Endocrinology, 11, pp. 456-459, (1986)
[7] Adashi E.Y., Resnick C.E., Hernandez E.R., Svoboda M.E., Van Wyk J.J., Characterization and regulation of a specific cell membrane receptor for somatomedin-C/insulin-like growth factor I in cultured rat granulosa cells, Endocrinology, 11, pp. 194-201, (1988)
[8] Adashi E.Y., Resnick C.E., Svoboda M.E., Van Wyk J.J., In-vivo regulation of granulosa cells somatomedin-C/insulin-like growth factor-I receptors, Endocrinology, 12, pp. 1383-1390, (1988)
[9] Adashi E.Y., Resnick C.E., Hernandez E.R., Hurwitz A., Rosenfeld R.G., Ovarian granulosa cell-derived insulin-like growth factor (IGF) binding proteins: Constitutive release of low molecular weight, high-affinity IGF-selective species, Mol. Cell. Endocrinol, 74, pp. 175-185, (1990)
[10] Adashi E.Y., Resnick C.E., Hernandez E.R., Hurwitz A., Rosenfeld R.G., Follicle-stimulating hormone inhibits the constitutive release of insulin-like growth factor binding proteins by cultured rat ovarian granulosa cells, Endocrinology, 12, pp. 1305-1306, (1990)

← 1 2 3 4 5 6 7 8 →