INSULIN-LIKE GROWTH-FACTORS - THE OVARIAN CONNECTION

被引：100

作者：

ADASHI, EY

RESNICK, CE

HURWITZ, A

RICCIARELLI, E

HERNANDEZ, ER

ROBERTS, CT

LEROITH, D

ROSENFELD, R

机构：

[1] Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore

[2] NIH, NIDDK, Bethesda

[3] Pediatric Endocrinology, Stanford University Medical Center, Stanford

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 09期

关键词：

INSULIN-LIKE GROWTH FACTOR (IGF); IGFBP; RECEPTOR; CAMP; SYNERGISM;

D O I：

10.1093/oxfordjournals.humrep.a137514

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A large body of information now supports the existence of a complete intraovarian insulin-like growth factor (IGF) system replete with ligands, receptors, and binding proteins. Although much remains to be learned, the emerging consensus would suggest that the intraovarian IGF system is concerned largely with the amplification of gonadotrophin hormonal action for the facilitation of follicular growth and development. Future studies are likely to address the central issue of indispensability and the documentation of a meaningful in vivo role for this and related putative intraovarian regulators.

引用

页码：1213 / 1219

页数：7

共 73 条

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