Activation of the innate immune system by CpG oligodeoxynucleotides: immunoprotective activity and safety

被引：33

作者：

Klinman, DM ^{[1
]}

Kamstrup, S ^{[1
]}

Verthelyi, D ^{[1
]}

Gursel, I ^{[1
]}

Ishii, KJ ^{[1
]}

Takeshita, F ^{[1
]}

Gursel, M ^{[1
]}

机构：

[1] US FDA, Sect Retroviral Res, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

来源：

SPRINGER SEMINARS IN IMMUNOPATHOLOGY | 2000年 / 22卷 / 1-2期

关键词：

D O I：

10.1007/s002810050027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：173 / 183

页数：11

共 56 条

[21] EVIDENCE FOR AN ALPHA-BETA T-CELL INDEPENDENT MECHANISM OF RESISTANCE TO MYCOBACTERIA - BACILLUS-CALMETTE-GUERIN CAUSES PROGRESSIVE INFECTION IN SEVERE COMBINED IMMUNODEFICIENT MICE, BUT NOT IN NUDE-MICE OR IN MICE DEPLETED OF CD4+ AND CD8+ T-CELLS [J].

IZZO, AA ;

NORTH, RJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (02) :581-586

[22]

Jakob T, 1998, J IMMUNOL, V161, P3042

[23] Therapeutic applications of CpG-containing oligodeoxynucleotides [J].

Klinman, DM .

ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 1998, 8 (02) :181-184

[24]

Klinman DM, 1997, J IMMUNOL, V158, P3635

[25] CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma [J].

Klinman, DM ;

Yi, AK ;

Beaucage, SL ;

Conover, J ;

Krieg, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (07) :2879-2883

[26] CPG DNA - A PATHOGENIC FACTOR IN SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

KRIEG, AM .

JOURNAL OF CLINICAL IMMUNOLOGY, 1995, 15 (06) :284-292

[27] CPG MOTIFS IN BACTERIAL-DNA TRIGGER DIRECT B-CELL ACTIVATION [J].

KRIEG, AM ;

YI, AK ;

MATSON, S ;

WALDSCHMIDT, TJ ;

BISHOP, GA ;

TEASDALE, R ;

KORETZKY, GA ;

KLINMAN, DM .

NATURE, 1995, 374 (6522) :546-549

[28]

LE JM, 1989, LAB INVEST, V61, P588

[29] Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines [J].

Lipford, GB ;

Sparwasser, T ;

Bauer, M ;

Zimmermann, S ;

Koch, ES ;

Heeg, K ;

Wagner, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (12) :3420-3426

[30] SUBVERSION OF THE IMMUNE-SYSTEM BY PATHOGENS [J].

MARRACK, P ;

KAPPLER, J .

CELL, 1994, 76 (02) :323-332

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