A hierarchical self-assembly of eumelanin

被引:76
作者
Clancy, CMR
Nofsinger, JB
Hanks, RK
Simon, JD [1 ]
机构
[1] Duke Univ, Dept Chem, Durham, NC 27708 USA
[2] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA
关键词
D O I
10.1021/jp001630q
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Atomic force microscopy is used to examine the structure of a natural eumelanin isolated from the ink sacs of cuttlefish (Sepia officinalis). The experimental data presented clearly show that the 100-200 nm spherical eumelanin particles imaged previously by SEM are not a fundamental structural unit. While these spherical particles are stable structures, as is evidenced by their cohesiveness under mechanical stress, the AFM images reveal that these particles are composed of smaller constituents. Taking recent scattering and mass spectrometry results into consideration, we conclude that the self-assembly of Sepia eumelanin is a hierarchical process with small units assembling into hundred-nanometer structures, which then aggregate to form the morphology of the macroscopic pigment.
引用
收藏
页码:7871 / 7873
页数:3
相关论文
共 19 条
[1]   BIOSYNTHESIS OF MELANIN FROM DOPAMINE - AN INVESTIGATION OF EARLY OLIGOMERIZATION PRODUCTS [J].
BERTAZZO, A ;
COSTA, C ;
ALLEGRI, G ;
SERAGLIA, R ;
TRALDI, P .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1995, 9 (08) :634-640
[2]  
Bertazzo A, 1999, RAPID COMMUN MASS SP, V13, P542, DOI 10.1002/(SICI)1097-0231(19990330)13:6<542::AID-RCM521>3.0.CO
[3]  
2-H
[4]  
CHIO S, 1977, THESIS U HOUSTON HOU
[5]   MELANIN BIOSYNTHESIS FROM DOPAMINE .2. A MASS-SPECTROMETRIC AND COLLISIONAL SPECTROSCOPIC INVESTIGATION [J].
COSTA, C ;
BERTAZZO, A ;
ALLEGRI, G ;
TOFFANO, G ;
CURCURUTO, O ;
TRALDI, P .
PIGMENT CELL RESEARCH, 1992, 5 (03) :122-131
[6]   Solution structure of copper ion-induced molecular aggregates of tyrosine melanin [J].
Gallas, JM ;
Littrell, KC ;
Seifert, S ;
Zajac, GW ;
Thiyagarajan, P .
BIOPHYSICAL JOURNAL, 1999, 77 (02) :1135-1142
[7]   EUMELANIN AND PHEOMELANIN CONTENTS OF HUMAN EPIDERMIS AND CULTURED MELANOCYTES [J].
HUNT, G ;
KYNE, S ;
ITO, S ;
WAKAMATSU, K ;
TODD, C ;
THODY, AJ .
PIGMENT CELL RESEARCH, 1995, 8 (04) :202-208
[8]   PHOTOPROTECTION BY MELANIN [J].
KOLLIAS, N ;
SAYRE, RM ;
ZEISE, L ;
CHEDEKEL, MR .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1991, 9 (02) :135-160
[9]  
KROESCHE C, 1996, TETRAHEDRON, P52
[10]  
Napolitano A, 1996, RAPID COMMUN MASS SP, V10, P468, DOI 10.1002/(SICI)1097-0231(19960315)10:4<468::AID-RCM506>3.3.CO